ANALYSIS OF THE ERYTHROCYTE ALLOIMMUNIZATION PROFILE OF WOMEN WITH BREAST CANCER AT THE NATIONAL CANCER INSTITUTE
Keywords:
Women’s health, breast neoplasms, blood group antigens, isoantibodiesAbstract
Objective: To describe the erythrocyte alloimmunization profile of women diagnosed with breast cancer at the National Cancer Institute, based on a comparison between routine antibody and irregular enzyme techniques. Methods: Experimental and prospective study with the application of human antiglobulin techniques and enzymatic technique in the search for irregular antibodies in pretransfusion tests of women with breast cancer treated at the hemotherapy service of Hospital do Câncer III, between June 2015 and May 2016. The variables were compared using Pearson’s χ2 test or G-test, when indicated. Results: 429 cases were included. Of the total, 8 (1.86%) presented positive antibody screening test in routine human antiglobulin technique, while 32 (7.6%) were observed in the enzymatic technique. Significant differences were observed between alloimmunized and non-alloimmunized patients regarding ethnicity, RhD classification, transfusion history and alloantibody incidence time. Conclusion: The application of the enzymatic technique is proposed as a routine method in patients with breast cancer, as a way of avoiding transfusion reactions and ineffective phenotype transfusions.
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Copyright (c) 2017 Renato Nascimento da Costa, Flávia Leite Souza Santos, Rodrigo do Tocantis Calado, Margarida de Oliveira Pinho, Simone Santos Peniche Rebouças, Bárbara de Queiroz Gadelha
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