PAGET’S DISEASE OF THE BREAST
STUDY OF CASES SERIES
Keywords:
Paget’s disease, mammary, breast, breast diseases, breast neoplasms, eczemaAbstract
Objective: To evaluate the survival of a series of patients with Paget’s disease of the breast. Methods: Observational, retrospective and descriptive study. Data were collected through electronic medical records; the following variables were obtained: age, tumor histology, tumor size, degree of differentiation, lymphatic invasion, vascular invasion, neural invasion, presence or not of potential involvement of axillary lymph nodes, immunohistochemical profile, treatments performed, recurrence, and follow-up. Results: Of the 301 cases of assisted breast cancer, six patients were identified with Paget’s disease of the breast. The overall survival, with a mean follow-up of 54 months, was 100%. All individuals are free of disease activity. The most common histochemical profile was negative for estrogen and progesterone receptors, and positive for HER-2/neu. Axillary and/or distal metastatic involvement was not identified. Conclusions: Overall survival was 100%, with a mean follow-up of 54 months. This high rate is due to the absence of axillary and/or distal metastatic involvement in our series.
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References
Beltran C, Orlandini V, Stokkermans-Dubois J, Vergier B, Fauchier JM, Doutre MS, et al. Maladie de Paget mammaire pigmentée. Ann Dermatol Venereol. 2008;135:211-6.
Lee HW, Kim TE, Cho SY, Kim SW, Kil WH, Lee JE, et al. Invasive Paget disease of the breast: 20 years of experience at a single institution. Hum Pathol. 2014;45:2480-7.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME. Paget’s disease of the nipple. Breast Cancer Res Treat. 2013;141:1-12.
Albarrán JM, Gadea C, Saldivia F, Prince J, Ramos S, Gutierrez N, et al. Enfermedad de Paget de la mama. Reporte de 13 casos. Rev Venez Oncol. 2010;22:194-200.
Cirqueira MB, Soares LR, Moreira MAR, Rosa VDL, Freitas-Junior R. Doença de Paget da mama: experiência de um centro universitário. Rev Bras Mastologia. 2015;25:90-6.
Lopes Filho LL, Lopes IMRS, Lopes LRS, Enokihara MMSS, Michalany AO, Matsunaga N. Mammary and extramammary Paget’s disease. Ann Bras Dermatol. 2015;90:225-31.
Sek P, Zawrocki A, Biernat W, Piekarski JH. HER2 molecular subtype is dominant subtype of mammary Paget’s cells. An immunohistochemical study. An immunohistochemical study. Histopathology. 2010;57:564-71.
Caliskan M, Gatti G, Sosnovskikh I, Rotmensz N, Botteri E, Musmeci S, et al. Paget’s disease of the breast: The experience of the European Institute of Oncology and review of the literature. Breast Cancer Res Treat. 2008;112:513-21.
Marczyk E, Kruczak A, Ambicka A, Mularz K, Harazin-Lechowska A, Moskal J, et al. The routine immunohistochemical evaluation in Paget disease of the nipple. Pol J Pathol. 2011;62:229-35.
Hanna W, Alowami S, Malik A. The role of HER-2/neu oncogene and vimentin filaments in the production of the Paget’s phenotype. Breast J. 2003;9:485-90.
Li YJ, Huang XE, Zhou XD. Local Breast Cancer Recurrence after Mastectomy and Breast-Conserving Surgery for Paget’s Disease: A Meta-Analysis. Breast Care (Basel). 2014;9(6):431-4.
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Copyright (c) 2017 Walberto Monteiro Neiva Eulálio Filho, Flávia Vanessa Carvalho Sousa Esteves, Taíla Sousa de Moura Fé, Luan Barbosa Furtado, Raimundo Gerônimo da Silva Junior, Sabas Carlos Vieira
This work is licensed under a Creative Commons Attribution 4.0 International License.
