BREAST METASTASIS OF A CUTANEOUS SQUAMOUS CELL CARCINOMA
CASE REPORT
Keywords:
Squamous cell carcinoma, Breast neoplasms, Neoplasm metastasis, Mastectomy, PathologyAbstract
Breast cancer is the most frequent malignant tumor in women. However, squamous cell carcinoma (SCC) of the breast is very rare. Several pathological criteria are required to establish a firm diagnosis of primary SCC of the breast: 1) the tumor origin must be independent from the overlying skin and nipple; 2) the infiltrating component of the breast cancer must be predominantly of squamous type (>90%); 3) no other invasive neoplastic elements, ductal, mesenchymal or otherwise, must be present in the tumor; 4) another site of primary SCC in the patient must have been excluded. The metastatic lesion involving the breast may occur due to a metastasis from a contralateral mammary cancer or originate in any extramammary site. Breast metastases do not normally express estrogen, progesterone receptors or Human Epidermal growth factor Receptor-type 2 (HER2) protein. Prognosis is poor and treatment is palliative, based on systemic therapy tailored to the primary cancer, sometimes completed by comfort locoregional treatment of the breast lesion. The present study reports the case of a woman previously treated for cutaneous SCC with breast metastasis, but more studies of these rare tumors are needed to increase our knowledge and improve patients’ outcomes.
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Copyright (c) 2018 Mauro Fróes Assunção, Larissa Santana Bitencourt, Patrícia Lopes de Brito, Sérgio Figueiredo Calmon Filho, Daniela Cristina Camarotti Camara Escorel Ribeiro, André Vinícius Moraes Dias, Marinalva Oliveira Medina da Silva Filha, Lívia Senna Pinheiro Santos Lima
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