BREAST CANCER SURVIVAL IN A BRAZILIAN CANCER CENTER
A COHORT STUDY OF 5,095 PATIENTS
Keywords:
breast cancer, survival, cancer staging, cancer hospital, Brazil, South AmericaAbstract
Objectives: To describe the age group, clinical stage at diagnosis, treatment, and survival rates of breast cancer patients treated in a Brazilian specialized Cancer Center. Method: A hospital-based retrospective cohort study is presented herein, on women with breast cancer diagnosed between January 1, 2000 and December 31, 2012. Data were extracted from the Hospital Cancer Registry of the A.C.Camargo Cancer Center. Data on age group, histology of the tumor, TNM classification, clinical stage and treatments were described in absolute and relative frequencies for three periods. Survival curves were estimated with the Kaplan-Meier estimator. Hazard ratio (HR) and 95% confidence interval (95%CI) were calculated for all variables. Results: A total of 5,095 female breast cancer patients were identified, with most stages classified as I and II (60%). The overall survival was 82.7% for the period of 2000–2004, and 89.9% for 2010–2012 (p<0.001). Patients with invasive ductal carcinoma, who were treated with surgery and hormonal therapy, showed a reduction in the risk of death in the most recent period HRadj=0.42 (95%CI 0.34–0.53) (2010–2012). Conclusions: Early stage diagnosis and combined treatment (including HT) are predictive prognostic factors for high survival rates in patients with invasive breast cancer. Specialized cancer centers can provide valuable indications regarding cancer control policies, evaluating overall survival for breast cancer and its associated prognosis.
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Copyright (c) 2019 Fabiana Baroni Makdissi, Fernanda Perez Magnani Leite, Stela Verzinhasse Peres, Diego Rodrigues Mendonça e Silva, Max Moura de Oliveira, Rossana Veronica Mendonza Lopez, Solange Moraes Sanches, Guilherme Rocha Melo Gondim, Hirofumi Iyeyasu, Vinicius Fernando Calsavara, Maria Paula Curado
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