BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA IN LI-FRAUMENI SYNDROME
CASE-BASED LITERATURE REVIEW
Keywords:
lymphoma, Li-Fraumeni syndrome, breast implants, breast cancer, anaplastic large cell lymphomaAbstract
Breast implant-associated anaplastic large cell lymphoma is a rare disease related to chronic seroma around breast implants. Breast implant-associated anaplastic large cell lymphoma has been recently recognized by the World Health Organization as a type of T-cell non-Hodgkin lymphoma of the breast. The main features comprise chronic seroma which develops a year posterior to breast surgery, with symptoms such as breast pain, swelling, skin hyperemia and a nodule or mass of the breast. Li-Fraumeni Syndrome is associated with germline TP53 mutation and enhances the risks of developing many types of cancers, including breast and hematologic malignancies. We report a case of a 56-year-old female with Li-Fraumeni Syndrome and a history of breast cancer who underwent a mastectomy to treat breast cancer and prophylactic contralateral nipple-sparing mastectomy followed by bilateral breast implant reconstruction with textured silicone implants. This patient developed Breast implant-associated anaplastic large cell lymphoma seven years later. A literature review on multidisciplinary approach to this condition was performed.
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Keech JA Jr., Creech BJ. Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg. 1997;100(2):554-5. https://doi.org/10.1097/00006534-199708000-00065
Clemens MW, Horwitz SM. NCCN Consensus Guidelines for the Diagnosis and Management of Breast Implant- Associated Anaplastic Large Cell Lymphoma. Aesthet Surg J. 2017;37(3):285-9. https://doi.org/10.1093/asj/sjw259
Doren EL, Miranda RN, Selber JC, Garvey PB, Liu J, Medeiros LJ, et al. U.S. epidemiology of breast implant-associated anaplastic large cell lymphoma. Plast Reconstr Surg. 2017;139(5):1042-50. https://doi.org/10.1097/PRS.0000000000003282
Mehta-Shah N, Clemens MW, Horwitz SM. How I treat breast implant-associated anaplastic large cell lymphoma. Blood. 2018;132(18):1889-98. https://doi.org/10.1182/blood-2018-03-785972
Rastogi P, Deva AK, Prince HM. Breast Implant-Associated Anaplastic Large Cell Lymphoma. Curr Hematol Malig Rep. 2018;13(6):516-24. https://doi.org/10.1007/s11899-018-0478-2
Malkin D. Li-Fraumeni syndrome. Genes Cancer. 2011;2(4):475‑84. https://doi.org/10.1177/1947601911413466
Amadou A, Waddington Achatz MI, Hainaut P. Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome. Curr Opin Oncol. 2018;30(1):23-9. https://doi.org/10.1097/CCO.0000000000000423
Valdez JM, Nichols KE, Kesserwan C. Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition. Br J Haematol. 2017;176(4):539-52. https://doi.org/10.1111/bjh.14461
Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwits S, et al. Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma. J Clin Oncol. 2016;34(2):160-8. https://doi.org/10.1200/JCO.2015.63.3412
Loch-Wilkinson A, Beath KJ, Knight RJW, Wessels WLF, Magnusson M, Papadopoulos T, et al. Breast implant‑associated anaplastic large cell lymphoma in Australia and New Zealand: high-surface-area texture implants are associated with increased risk. Plast Reconstr Surg. 2017;140(4):645-54. https://doi.org/10.1097/PRS.0000000000003654
Hu H, Jacombs A, Vickery K, Merten SL, Pennington DG, Deva AK. Chronic biofilm infection in breast implants is associated with an increased T-cell lymphocytic infiltrate: implications for breast implant-associated lymphoma. Plast Reconstr Surg. 2015;135(2):319-29. https://doi.org/10.1097/ PRS.0000000000000886
Miranda RN, Aladily TN, Prince HM, Kanagal-Shamanna R, de Jong D, Fayad LE, et al. Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients. J Clin Oncol. 2014;32(2):114-20. https://doi.org/10.1200/JCO.2013.52.7911
Laurent C, Delas A, Gaulard P, Haioun C, Moreau A, Xerri L, et al. Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes. Ann Oncol. 2016;27(2):306-14. https://doi.org/10.1093/annonc/mdv575
Mai PL, Best AF, Peters JA, DeCastro RM, Khincha PP, Loud JT, et al. Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li- Fraumeni syndrome cohort. Cancer. 2016;122(23):3673-81. https://doi.org/10.1002/cncr.30248
Lee YS, Filie A, Arthur D, Fojo AT, Jaffe ES. Breast implantassociated anaplastic large cell lymphoma in a patient with Li- Fraumeni syndrome. Histopathology. 2015;67(6):925-7. https://doi.org/10.1111/his.12737
Giacomazzi J, Graudenz MS, Osorio SABT, Koehler-Santos P, Palmero EI, Zagonel-Oliveira M, et al. Prevalence of the TP53 p.R337H mutation in breast cancer patients in Brazil. PLoS One. 2014;9(6):e99893. https://doi.org/10.1371/journal.pone.0099893
Lee YS, Filie A, Arthur D, Fojo AT, Jaffe ES. Breast implantassociated anaplastic large cell lymphoma in a patient with Li- Fraumeni syndrome. Histopathology. 2015;67(6):925-7. https://doi.org/10.1111/his.12737
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non- Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059-67. https://doi.org/10.1200/JCO.2013.54.8800
Clemens MW, Brody GS, Mahabir RC, Miranda RN. How to Diagnose and Treat Breast Implant-Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2018;141(4):586e-599e. https://doi.org/10.1097/PRS.0000000000004262
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Copyright (c) 2019 Marina Sonagli, Camila Souza Guatelli, Maria Nirvana da Cruz Formiga, Joel Abdala Junior, Almir Galvão Vieria Bittencourt, Fabiana Baroni Makdissi
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