Impact of mammography screening on the treatment of women diagnosed with breast cancer
Keywords:
mammography, breast neoplasms, mass screening, prognosis, combined modality therapyAbstract
Objective: To evaluate the influence of mammographic screening on the treatment of women with previous diagnosis of breast cancer. Method: Cross-sectional, descriptive, observational study, with primary and secondary data collection and quantitative approach. It was performed in a high complexity hospital in the South region of Santa Catarina, Brazil, where patients with previous history of breast cancer were evaluated during the period from 2012 to 2017, and who were undergoing oncological follow-up at the same hospital. The variables were expressed as frequency and percentage. Inferential statistical analyses were performed with a significance level of alpha = 0.05 and, therefore, 95% confidence interval. Therefore, the confidence interval was 95%. Associations between variables were investigated using the Pearson’s χ² and the likelihood ratio tests. Results: Among the 99 analyzed patients, 58.6% annually performed the examination and 49.5% had elapsed less than 12 months between the last performed mammogram and the diagnosis. There was a higher frequency of stage I disease, corroborating the results that 74.7% of patients underwent breastconserving surgeries and 68.7% underwent sentinel lymph node biopsy, rather than extensive surgeries. Regarding the treatment of choice, patients with annual or biennial mammographic frequency had similar surgical and chemotherapeutic outcomes in relation to patients who had a mammogram without defined frequency or who had never undergone it. Conclusion: Patients who underwent mammography on an annual frequency and those whose time between the last mammogram and the diagnosis of cancer was less than 12 months had tumors of lesser extent at diagnosis; however, it did not influence the type of treatment chosen.
Downloads
References
Lukong KE, Ogunbolude Y, Kamdem JP. Breast cancer in Africa: prevalence, treatment options, herbal medicines, and socioeconomic determinants. Breast Cancer Res Treat. 2017;166(2):351-65. Breast cancer in Africa: prevalence, treatment options, herbal medicines, and socioeconomic determinants. Breast Cancer Res Treat.
Instituto Nacional de Câncer Jose Alencar Gomes da Silva. Programa Controle de Câncer de Mama [Internet]. Brazil: INCA; 2018 [accessed on Oct. 27, 2018]. Available from: https://www.inca.gov.br/tipos-de-cancer/cancer-de-mama/profissional-de-saude
Instituto Nacional de Câncer Jose Alencar Gomes da Silva. Estimativa 2018: Incidência de Câncer no Brasil [Internet]. Rio de Janeiro: Ministério da Saúde; 2018 [accessed on Oct. 16, 2018]. Available from: http://www.epi.uff.br/wp-content/uploads/2013/08/estimativa-incidencia-de-cancer-nobrasil-2018.pdf
Yeo SK, Guan JL. Breast cancer: multiple subtypes within a tumor? Trends Cancer. 2017; 3(11):753-60. https://doi.org/10.1016/j.trecan.2017.09.001
Vuong D, Simpson PT, Green B, Cummings MC, Lakhani SR. Molecular classification of breast cancer. Virchows Arch. 2014;465(1):1-14. https://doi.org/10.1007/s00428-014-1593-7
Ahn S, Wooster M, Valente C, Moshier E, Meng R, Pisapati K, et al. Impact of screening mammography on treatment in women diagnosed with breast cancer. Ann Surg Oncol. 2018;25(10):2979-86. https://doi.org/10.1245/s10434-018-6646-8
Lebron-Zapata L, Jochelson MS. Overview of Breast Cancer Screening and Diagnosis. PET Clin. 2018;13(3):301-23. https://doi.org/10.1016/j.cpet.2018.02.001
Barth Jr. RJ, Gibson GR, Carney PA, Mott LA, Becher RD, Poplack SP. Detection of breast cancer on screening mammography allows patients to be treated with less-toxic therapy. AJR Am J Roentgenol. 2005;184(1):324-9. https://doi.org/10.2214/ajr.184.1.01840324
Merino Bonilla JA, Torres Tabanera M, Ros Mendoza LH. El cáncer de mama en el siglo XXI: de la detección precoz a los nuevos tratamientos. Radiología. 2017;59(5):368-79. https://doi.org/10.1016/j.rx.2017.06.003
Sarosiek T. Systemic treatment of early breast cancer – current state of knowledge after the conference St Gallen 2017. Pol Merkur Lekarski. 2017;43(257):232-6.
Matsen CB, Neumayer LA. Breast Cancer: a review for the general surgery. JAMA Surg. 2013;148(10):971-9. https://doi.org/10.1001/jamasurg.2013.3393
Urban LABD, Schaefer MB, Duarte DL, Santos RP, Maranhão NMA, Kefalas AL, et al. Recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para rastreamento do câncer de mama por métodos de imagem. Radiol Bras. 2012;45(6):334-9. https://doi.org/10.1590/S0100-39842012000600009
Miglioretti DL, Zhu W, Kerlikowske K, Sprague BL, Onega T, Buist DSM, et al. Breast Tumor Prognostic Characteristics and Biennial vs Annual Mammography, Age, 549 and Menopausal Status. JAMA Oncol. 2015;1(8):1069-77. https://doi.org/10.1001/jamaoncol.2015.3084
Ribeiro RA, Caleffi M, Polanczyk CA. Custo-efetividade de um programa de rastreamento organizado de câncer de mama no Sul do Brasil. Cad Saúde Pública. 2013;29(Suppl. 1):s131-s145. https://doi.org/10.1590/0102-311X00005213
Coleman C. Early Detection and Screening for Breast Cancer. Semin Oncol Nurs. 2017;33(2):141-55. https://doi.org/10.1016/j. soncn.2017.02.009
American Cancer Society. Breast cancer stages [Internet]. American Cancer Society; 2017 [accessed on Nov. 14, 2018]. Available from: https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/stages-of-breastcancer.html
McDonald ES, Clark AS, Tchou J, Zhang P, Freedman GM.Clinical diagnosis and management of breast cancer. J Nucl Med. 2016;57(Suppl. 1):9S-16S. https://doi.org/10.2967/jnumed.115.157834
Veronesi U, Galimberti V, Mariani L, Gatti G, Paganelli G, Viale G, et al. Sentinel node biopsy in breast cancer: early results in 953 patients with negative sentinel node biopsy and no axillary dissection. Eur J Cancer. 2005;41(2):231-7. https://doi.org/10.1016/j.ejca.2004.05.009
Warrier S, Tapia G, Goltsman D, Beith J. An update in breast cancer screening and management. Womens Health (Lond). 2016;12(2):229-39. https://doi.org/10.2217/whe.15.105
Migowski A, Silva GAE, Dias MBK, Diz MDPE, Sant’Ana DR, Nadanovsky P. Guidelines for early detection of breast cancer in Brazil. II - new national recommendations, main evidence, and controversies. Cad Saúde Pública. 2018;34(6):e00074817. http://dx.doi.org/10.1590/0102-311x00074817
Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15- year survival: an overview of the randomised trials. Lancet. 2005;366(9503):2087-106. https://doi.org/10.1016/s0140-6736(05)67887-7
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, et al. Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast. 2015;24(Suppl. 2):S26-S35. https://doi.org/10.1016/j.breast.2015.07.008
Duffy SW, Vulkan D, Cuckle H, Parmar D, Sheikh S, Smith RA, et al. Effect of mammographic screening from age 40 years on breast cancer mortality (UK Age trial): final results of a randomised, controlled trial.Lancet Oncol. 2020;21(9):1165-72. https://doi.org/10.1016/S1470-2045(20)30398-3
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Laura Ugioni, Laura Carminatti, Alessandra Beatris Rovaris, Luiza Ramos
This work is licensed under a Creative Commons Attribution 4.0 International License.