Investigation of the C3435T polymorphism in the MDR1 gene and its association with breast cancer in women of Mato Grosso, Brazil

Abstract

Objective: To investigate the frequency of the C3435T polymorphism in the MDR1 gene and its association with breast cancer (BC) in women of MT. Method: The study is descriptive and observational epidemiological case-control design. We analyzed the genotype of the C3435T polymorphism in the MDR1 gene in peripheral blood were compared in 201 patients with 177 controls. Patients were women with breast cancer, the controls were not women with BC confirmed by clinical examination and mammography. Data were collected through interviews with women, blood was collected for genotyping and data collection from medical records of patients. The project was approved by the Research Ethics Committee. Results: The C3435T polymorphism in the MDR1 gene had similar distribution between patients and controls with no statistically significant difference between samples. Conclusions: The frequency of C3435T polymorphism of MDR1 gene is similar to that found in the literature. We found no statistically significant difference in genotype frequency of C3435T polymorphism in the MDR1 gene among patients with BC and controls. The polymorphism also showed no association with prognosis for BC factors.