Genetics and epigenetics

molecular basis of initial formation of breast cancer

Authors

  • Alfredo Carlos Simões Dornellas de Barros Universidade de São Paulo

Keywords:

Breast neoplasms, genetics, Epigenesis genetic, Genes suppressor

Abstract

Breast cancer has monoclonal origin in stem-cells or progenitor cells by means of genetic (dependent on DNA damage) and epigenetic mechanisms (regardless of modifications in the DNA sequence). The process of suppressor genes inactivation necessary for mammary carcinogenesis initiation in sporadic (non-familial) or hereditary (familial) cancers, considering the two-hit model in the homologous chromosomes (Knudson theory) is herein presented. Genetic mutations are discussed as well as the epigenetic alterations that cause gene silencing, as DNA methylation, histones modifications and microRNA.

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Author Biography

Alfredo Carlos Simões Dornellas de Barros, Universidade de São Paulo

Núcleo de Mastologia do Hospital Sírio Libanês e Disciplina de Topografia Estrutural Humana da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo (SP), Brasil.

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Published

2010-01-28

How to Cite

Barros, A. C. S. D. de. (2010). Genetics and epigenetics: molecular basis of initial formation of breast cancer. Revista Brasileira De Mastologia, 20(1), 48–54. Retrieved from https://revistamastology.emnuvens.com.br/rbm/article/view/15

Issue

Vol. 20 No. 1 (2010)

Section

Artigo de Atualização

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.