Analysis of immunohistochemical markers associated with breast cancer in women in the Region of Missions, Rio Grande do Sul, Brazil

Abstract

Objectives: To analyze the molecular subtype’s breast cancer distribution and correlate them with age and histological profile. Methods: An observational, descriptive and retrospective study. One hundred and ten women with histological diagnosis of breast cancer and immunohistochemistry analysis, from January 2013 to December 2015, were included. From the reports, four molecular subtypes were defined: luminal A, luminal B, HER-2+ and triple negative. Correlations between molecular subtypes and histologic type and age were evaluated statistically. Results: The average age of the participants of the investigation was 56.9 years (SD=15.15), with a peak in the age group over 50 years. The most common histological type (66.4%) was invasive ductal carcinoma (IDC). The luminal B was the most frequent molecular subtype, representing 43.6% of cases. Conclusions: Based on molecular markers, the breast carcinomas were classified into four subtypes and showed neither significant difference regarding histologic type nor age.