Impact assessing of immunohistochemical hormone receptor status and Her-2 in breast cancer prognosis

Abstract

Breast cancer is a major cause of cancer related death in women, with more than one million new cases and as often as 410 thousands deaths in one year. The object of this study is confirm if there is a correlation of immune-histochemistry (hormonal receptors and Her-2) and prognostic of breast cancer. We carried out a systematic review on Pubmed, Scielo, Science Medic and Medline and excluded the review with animals or research that didn’t evaluate the effects of immune-histochemistry in prognostic breast cancer. We discovered 1.300 systematic reviews in Pubmed, 711 in Medline, 415 Science Medic and 139 Scielo with 2.255 articles. Among 2.255, we selected 18. We may conclude there is a great importance in a correlation of the immunohistochemistry and the prognostic breast cancer, but the articles are very controversial. We need to have a follow-up with these patients for a long time and better evaluation with clinic-pathologic factors