Plasma Levels of vitamin D and the breast cancer during the climacteric

a case-control study

Abstract

Objective: To evaluate the association between the plasma levels of 25-hydroxyvitamin D and the breast cancer in the climacteric. Methods: It is a kind of case-control study with women between 45 until 70 years old attended in clinics of mastology and ginecology of the maternal-infantile hospital Fernandes Figueira, localized in Rio de Janeiro city. Thirdy-nine incident cases of breast cancer and 60 controls were selected. The participants were submitted to an interview for filling out of a structured questionnaire and forthwith it was made the swab blood for the dosage of 25 OHD. Results: A prevalence of 80.8% of vitamin D deficiency (<30 ng/mL) was spotted among the participants of the study. In relation to the estimate of risk for breast cancer, the group with sufficient levels of 25 OHD did not present difference with significance statistic of the group with vitamin D deficiency. Nevertheless, during the analysis of the estimate of risk according to menopausal status, there were less chance of exposition and development of the breast cancer in postmenopaused women with sufficient levels of 25 OHD (OR 0.53; 95%CI 0.12–2.41) than the premenopaused women with normal levels of vitamin D (OR 0.97; 95%CI 0.13–8.35) when compared to the group with vitamin D deficiency. Conclusion: The results of this study suggests that the vitamin D deficiency among postmenopaused women is a factor of risk for the breast cancer during the climacteric. However, more studies are still necessary to confirm this association.