PASH
STROMAL AND PSEUDOANGIOMATOUS HYPERPLASIA — SURGICAL TREATMENT USING ONCOPLASTIC TECHNIQUES — THOREK AND DERMAL FLAP
Keywords:
Hyperplasia, neoplasms, breast, reconstructive surgical proceduresAbstract
Pseudoangiomatous stromal hyperplasia (PASH) is a benign and infrequent mammary pathology, characterized by abnormal proliferation of stromal cells forming a complex network of channels interconnected by vascular spaces, delineated by fusiform cells, originating from myofibroblastic cells. It is commonly found in breast biopsies as an incidental finding and, more rarely, it can form a nodular, tumorlike mass or exhibit a pattern of diffuse involvement of the breast parenchyma. It affects women aged between 18 and 45 years old and is related to hormonal stimulation. In most cases, PASH shows slow growth. The treatment recommended by most authors is a broad excision of the lesion, with free margins to avoid local recurrences. Surgical resection combined with breast reconstruction techniques allows the incorporation of concepts and techniques that respect aesthetics and improve women’s quality of life. This study aimed to report the case of a 40-year-old patient with multiple bilateral breast nodules, associated with ptotic hypertrophic mastopathy, treated by adenectomy and immediate reconstruction with mammary prosthesis using Thorek’s technique. The patient presented a good postoperative evolution, with excellent cosmetic results and no evidence of disease after 19 months of diagnosis.
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References
Vuitch MF, Rosen PP, Erlandson RA. Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 1986;17(2):185-91.
Wieman SM, Landercasper J, Johnson JM, Ellis RL, Wester SM, Lambert PJ, et al. Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg. 2008;74:1211-4.
Ibrahim RE, Sciotto CG, Weidner N. Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer. 1989;63:1154-60.
Milanezi MF, Saggioro FP, Zanati SG, Bazan R, Schmitt FC. Pseudoangiomatous hyperplasia of mammary stroma associated with gynaecomastia. J Clin Pathol. 1998;51:204-6.
Shehata BM, Fishman I, Collings MH, Wang J, Poulik JM, Ricketts RR, et al. Pseudoangiomatous stromal hyperplasia of the breast in pediatric patients: an underrecognized entity. Pediatr Dev Pathol. 2009;12:450-4. https://doi.org/10.2350/08-09-0528.1
Hargaden GC, Yeh ED, Georgian-Smith D, Moore RH, Rafferty EA, Halpern EF, et al. Analysis of the mammographic and sonographic features of pseudoangiomatous stromal hyperplasia. AJR Am J Roentgenol. 2008;191:359-63. https://doi.org/10.2214/AJR.07.2479
AbdullGaffar B. Pseudoangiomatous stromal hyperplasia of the breast. Arch Pathol Lab Med. 2009;133:1335-8. https://doi.org/10.1043/1543-2165-133.8.1335
Pruthi S, Reynolds C, Johnson RE, Gisvold JJ. Tamoxifen in the Management of Pseudoangiomatous Stromal Hyperplasia. Breast J. 2001;7(6):434-9.
Audretsch WP, Rezai M, Kolotas C, Zamboglou N, Schnabel T, Bojar H. Tumor-Specific Immediate Reconstruction in Breast Cancer Patients. Seminars Plastic Surgery. 1998;11(1):71-100. DOI: 10.1055/s-2008-1080243
Cyralk D, Carpenter PM. Breast imaging case of the day. Pseudoangiomatous stromal hyperplasia. RadioGraphics. 1999; 19:1086-8. https://doi.org/10.1148/radiographics.19.4.g99jl201086
Anderson C, Ricci A Jr., Pedersen CA, Cartun RW. Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. Am J Surg Pathol. 1991;15:145-9.
Ryu EM, Whang IY, Chang ED. Rapidly growing bilateral pseudoangiomatous stromal hyperplasia of the breast. Korean J Radiol. 2010;11(3):355-8. DOI: 10.3348/kjr.2010.11.3.355
Chagas CR, Menke CH, Vieira RJS, Boff RA. Tratado de mastologia da SBM. Rio de Janeiro: Revinter; 2011. p.479-81.
Cohen MA, Morrison EA, Rosen PP, Dershaw DD, Liberman L, Abramson AF. Pseudoangiomatous stromal hyperplasia: mammographic, sonographic and clinical patterns. Radiology. 1996;198:117-20. https://doi.org/10.1148/radiology.198.1.8539361
Kopans D. Breast Imaging. Filadélfia: Lippincott-Raven Publishers; 2007.
Nassar H, Elieff MP, Kronz JD, Argani P. Pseudoangiomatous stromal hyperplasia (PASH) of the breast with foci of morphologic malignancy: a case of pash with malignant transformation? Int J Surg Pathol. 2010;18:564-9. https://doi.org/10.1177/1066896908320835
Sng KK, Tan SM, Mancer JF, Tay KH. The contrasting presentation and management of pseudoangiomatous stromal hyperplasia of the breast. Singapore Med J. 2008;49:e82-5.
Powell CM, Cranor ML, Rosen PP. Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation. Am J Surg Pathol. 1995;19:270-7.
Piccoli CW, Feigi SA, Palazzo JP. Developing asymmetric breast tissue. Radiology. 1999;211:111-7. https://doi.org/10.1148/radiology.211.1.r99ap42111
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Copyright (c) 2018 Ana Carolina Guglielmelli Mendonça, Raffaela Levy de Andrade, Douglas de Miranda Pires

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