IMMUNOHISTOCHEMICAL PROFILE OF BREAST CANCER SUBTYPES IN PATIENTS SEEN AT NAPOLEÃO LAUREANO HOSPITAL, PARAÍBA, BRAZIL
Keywords:
breast cancer, carcinoma, ductal, immunohistochemistryAbstract
Objective: To determine the profile of molecular subtypes of invasive breast carcinomas among women who underwent immunohistochemical study from May 2013 to December 2014, at Hospital Napoleon Laureano, Paraiba, Brazil, to characterize the mean age at diagnosis and describe the percentage of the following variables: estrogen and progesterone receptors, human epidermal growth factor 2 and proliferation index (Ki-67). Method: retrospective ecological study using the secondary databases at Hospital Napoleon Laureano Pathology Laboratory. The population consisted of 683 cases of invasive breast carcinoma with immunohistochemical study in this institution between May 2013 and December 2014. Results: Of the 683 patients, 46 were excluded because they presented inconclusive results for human epidermal growth factor 2 (++), totaling 637 recorded cases. Five hundred and fifty-six (87.28%) were 40 or older, and 81 (12.72%) under 40 years old. As for estrogen and progesterone receptor, 452 patients (70.96%) were positive for both receptors, while 185 (29.04%) showed no positivity. Four hundred and sixty-eight women (73.47%) did not show overexpressed human epidermal growth factor 2, while 169 (26.53%) did. The percentage of Ki-67 showed 474 individuals (74.41%) with a high proliferation index and 163 (25.59%) with a low index. The molecular subtypes showed the following prevalence: luminal A (143 cases; 22.45%), luminal B (250 cases; 39.25%), luminal B-enriched (113 cases; 17.84%), HER2 (57 cases; 8.95%) and triple-negative (74 cases; 11.62%). Conclusion: This study supported the notion of regional differences in the profile of breast tumors, since it showed a greater prevalence of triple-positive carcinomas and lower frequency of triple-negative tumors compared to studies of other Brazilian regions.
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Ferlay J, SoerjomataramI, Dikshit R,Eser S, Mathers C, Rebelo M, et al. Cancer. Incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359-86.
Instituto Nacional de Cancer. Coordenacao de Prevencao e Vigilancia. Programa Nacional de Controle do Cancer de Mama. Estimativa 2016: incidencia de cancer no Brasil. Rio de Janeiro: INCA; 2015. 122p..
Dai X, Li T, Bai Z, Yang Y, Liu X, Zhan J, et al. Breast cancer intrinsic subtype classification, clinical use and future trends. Am J Cancer Res. 2015;5(10):2929-43.
Serra KP, Ramalho S, Torresan R, Vassallo J, Sarian LOZ, Silva GRP, et al. Nova classificacao dos carcinomas da mama: procurando o luminal A. Rev Bras Ginecol Obstet. 2014; 36(12):575-80. http://dx.doi.org/10.1590/SO100-720320140005158
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747-52. https://doi.org/10.1038/35021093
Barros ACSD, Leite KRM. Classificacao molecular dos carcinomas de mama. Uma visao contemporanea. Rev Bras Mastologia. 2015;25(4):146-55. http://dx.doi.org/10.1590/S0104-42302012000200013
Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart- Gebhart M, Thurlimann B, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013; 24(9):2206-23. https://doi.org/10.1093/annonc/mdt303
Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, et al. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011;22(8):1736-47. http://dx.doi.org/10.1590/S0104-42302012000200013
Cintra JRD, Teixeira MTB, Diniz RW, Goncalves Junior H, Florentino TM, Freitas GF, et al. Perfil imuno-histoquimico e variaveis clinicopatologicas no cancer de mama. Rev Assoc Med Bras. 2012; 58(2):178-87. http://dx.doi.org/10.1590/S0104-42302012000200013
Morrow M. Personalizing extent of breast cancer surgery according to molecular subtypes. Breast. 2013; 22(Supl. 2):S106-9. https://doi.org/10.1016/j.breast.2013.07.020
Chikarmane SA, Tirumani SH, Howard SA, Jagannathan JP, DiPiro PJ. Metastatic patterns of breast cancer subtypes: What radiologists should know in the era of personalized cancer medicine. Clin Radiol. 2015;70(1):1-10. https://doi.org/10.1016/j.crad.2014.08.015
Dunbier AK, Anderson H, Ghazoui Z, Salter J, Parker JS, Perou CM, et al. Association between breast cancer subtypes and response to neoadjuvant anastrozole. Steroids. 2011; 76(8):736‑40. https://doi.org/10.1016/j.steroids.2011.02.025
Martelli G, Boracchi P, Ardoino I, Lozza L, Bohm S, Vetrella G, et al. Axillarydissection versus no axillary dissection in older patients with T1N0 breast cancer: 15-year results of a randomized controlled trial. Ann Surg. 2012;256(6):920-4. https://doi.org/10.1097/SLA.0b013e31827660a8
Carvalho FM, Bacchi LM, Pincerato KM, Van de Rijn M, Bacchi CE. Geographic differences in the distribution of molecular subtypes of breast cancer in Brazil. BMC Women’s Health. 2014;14:102. https://doi.org/10.1186/1472-6874-14-102
Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol. 2010;28(16):2784-95. https://doi.org/10.1200/JCO.2009.25.6529
Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. J Clin Oncol. 2013;31(31):3997‑4013. https://doi.org/10.1200/JCO.2013.50.9984
Gabriel CA, Domchek SM. Breast cancer in young women. Breast Cancer Res. 2010;12:212. https://doi.org/10.1186/bcr2647
Clagnan WS, Andrade JM, Carrara HHA, Tiezzi DG, Reis FJC, Marana HRC, et al. Idade como fator independente de prognostico no cancer de mama. Age as an independent prognostic factor in breast cancer. Rev Bras Ginecol Obstet. 2008;30(2):67-74. http://dx.doi.org/10.1590/S010072032008000200004
Dutra MC, Rezende MA, Andrade VP, Soares FA, Ribeiro MV, Paula EC, et al. Imunofenotipo e evolucao de cancer de mama: comparacao entre mulheres muito jovens e mulheres na pos-menopausa. Immunophenotype and evolution of breast carcinomas: a comparison between very young and postmenopausal women. Rev Bras Ginecol Obstet. 2009;31(2):54‑60. http://dx.doi.org/10.1590/S0100-72032009000200002
Assi HA, Khoury KE, Dbouk H, Khalil LE, Mouhieddine TH, El Saghir NS. Epidemiology and prognosis of breast cancer in young women. J Thorac Dis. 2013;5:(Supl.1):S2-8. https://dx.doi.org/10.3978%2Fj.issn.2072-1439.2013.05
Sarturi PR, Cunha Junior AD, Morais CF. Perfil imunohistoquimico do cancer de mama de pacientes atendidas no Hospital do Cancer de Cascavel – Parana. Rev Bras Oncol Clin. 2012;8(29):121-4.
Chuang E, Christos P, Flam A, McCarville K, Forst M, Shin S, et al. Breast cancer subtypes in Asian-Americans differ according to Asian ethnic group. J Immigr Minor Health. 2012;14(5):754‑8. https://dx.doi.org/10.1007%2Fs10903-012-9577-7
Kurian AW, Fish K, Shema SJ, Clarke CA. Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups. Breast Cancer Res. 2010;12(6):R99. https://dx.doi.org/10.1186%2Fbcr2780
Huo D, Ikpatt F, Khramtsov A, Dangou JM, Nanda R, Dignam J, et al. Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer. Clin Oncol. 27(27):4515-21. https://doi.org/10.1200/JCO.2008.19.6873
Instituto Brasileiro de Geografia e Estatistica. Censo Demografico 2010, [Internet]. Rio de Janeiro: Instituto Brasileiro de Geografia e Estatistica; 2012 [acessado em jun. 2016]. Disponivel em: http://www.ibge.gov.br/home/estatistica/populacao/censo2010
Keegan THM, DeRouen MC, Press DJ, Kurian AW, Clarke CA. Occurrence of breast cancer subtypes in adolescente and young adult women. Breast Cancer Res. 2012;14(2): R55. https://dx.doi.org/10.1186%2Fbcr3156
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Copyright (c) 2019 Jader Bruno Formiga Pinheiro, Adriana de Freitas Torres, Alexandre Rolim da Paz
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