CHARACTERIZATION OF PROGNOSTIC FACTORS OF BREAST CANCER AMONG WOMEN WITH THIS CONDITION ATTENDED BY THE BRAZILIAN UNIFIED HEALTH SYSTEM IN THE MUNICIPALITY OF BAGÉ, RIO GRANDE DO SUL, BRAZIL
Keywords:
breast neoplasms, immunohistochemistry, prognosisAbstract
Objective: This study aimed to characterize the prognostic factors of breast cancer among women with this pathology treated by the Brazilian Unified Health System in the Municipality of Bagé, Rio Grande do Sul, which comprises the municipalities of the 7th Regional Health Coordination. Methods: This study was documentary, retrospective and quantitative in nature and based on the analysis of the medical records of patients undergoing cancer treatment who were attended at the oncological treatment unit in Bagé, from December 2010 to June 2017. Results: The results showed a total of 349 patients with breast cancer in the analyzed period, and their age ranged from 24 to 90 years, with the highest frequency presenting in white women in the left breast (42%). Most of the cancers were smaller than 2 cm (53.9%), with no lymph node involvement (57%) and without distant metastases (93.4%), and the majority of patients were diagnosed in the early stages, I (36.4% %) and II (32.4%). Regarding the anatomopathological and immunohistochemical characteristics, invasive ductal carcinoma was the most common type (79.7%), the histological grade II was present in more than half of cases (56.5%), and 78.8% of the patients presented with the expression of hormone receptors, whereas 16% had HER2 overexpression; the luminal subtype B was present in 64.8% of the patients. Conclusion: Thus, it is noted that most patients are diagnosed in the early stages. Nonetheless, it is still necessary to adopt measures that guarantee diagnosis in pre-invasive phases.
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Cesar PGC, Fonseca FLA, Gehrke FS, Alves BCA, Kuniyoshi RK, Del Giglio A. Utilizacao de plataforma genica no prognostico. Arq Bras Cien Saude. 2012;37(3):154-61.
Brasil. Ministerio da Saude. Instituto Nacional do Cancer. Estimativas - 2018: Incidencia de Cancer no Brasil [Internet]. Brasil: Ministerio da Saude; 2018 [acessado em16 out. 2018]. Disponivel em: http://www.inca.gov.br/estimativa/2018/estimativa-2018.pdf
Cintra JRD, Teixeira MTB, Diniz RW, Goncalves Junior H, Florentino TM, Freitas GF, et al. Perfil imuno-histoquimico e variaveis clinicopatologicas no cancer de. Rev Assoc Med Bras. 2012;58(2):178-87. http://dx.doi.org/10.1590/S0104- 42302012000200013
Lima ALP, Rolim NCOP, Gama MEA, Pestana AL, Silva EL, Cunha CLF. Rastreamento oportunistico do cancer de mama entre mulheres jovens no estado do Maranhao, Brasil. Cad Saude Publica. 2011;27(7):1433-39. http://dx.doi.org/10.1590/ S0102-311X2011000700018 REFERENCES
Correia SB, Souza FB, Abrahao DPS, Abdalla DR, Carvalho EEV, Abdalla JK. Prevalencia de pacientes jovens diagnosticadas com cancer de mama e em tratamento na cidade de Uberaba – MG. J Contextual Behav Sci. 2015;1(1):28-32.
Paluch-Shimon S, Pagani O, Partridge AH, Abulkhair O, Cardoso MJ, Dent RA, et al. ESO-ESMO 3rd international consensus guidelines for breast cancer in. Breast. 2017;35:203‑17. https:// doi.org/10.1016/j.breast.2017.07.017
Sharma D, Singh G. Breast cancer in young women: A retrospective study from tertiary care. South Asian J Cancer. 2017;6(2):51-3. https://dx.doi.org/10.4103%2F2278- 330X.208859
Matos JC, Pelloso SM, Carvalho MDB. Fatores associados a realizacao da prevencao secundaria do cancer de mama no Municipio de Maringa, Parana, Brasil. Cad Saude Publica. 2011;27(5):888-98. http://dx.doi.org/10.1590/S0102- 311X2011000500007
Brasil. Ministerio da Saude. Lei no 11.664/2008. Dispoe sobre a efetivacao de acoes de saude que assegurem a prevencao, a deteccao, o tratamento e o seguimento dos canceres do colo uterino e de mama, no ambito do Sistema Unico de Saude - SUS [Internet]. Brasil: Ministerio da Saude; 2008 [acessado em set. 2017]. Disponivel em: http://www.planalto.gov.br/ ccivil_03/_Ato2007-2010/2008/Lei/L11664.htm
Moreno M, Biazi CL, Proner C. Cancer de mama na regiao oeste de Santa Catarina. Rev Bras Mastologia. 2012;22(4):111-6.
Moraes AB, Zanini RR, Turchiello MS, Riboldi J, Medeiros LR. Estudo da sobrevida de pacientes. Cad Saude Publica. 2006;22(10):2219-28. http://dx.doi.org/10.1590/S0102- 311X2006001000028
Goncalves LLC, Santos SB, Marinho EC, Almeida AM, Santos AHS, Barros AMMS, et al. Cancer de mama feminino: aspectos clinicos e patologicos dos casos cadastrados de 2005 a 2008 num servico publico de oncologia de Sergipe. Rev Bras Saude Materno Infantil. 2012;12(1):47-8. http://dx.doi.org/10.1590/ S1519-38292012000100005
Abreu E, Koifman S. Fatores prognosticos no cancer de mama feminino. Rev Bras Cancerologia. 2002;48(1):113-31.
Rosa LM, Radunz V. Taxa de sobrevida na mulher com cancer de mama: estudo de revisao. Texto Contexto Enferm. 2012;21(4):980‑9. http://dx.doi.org/10.1590/S0104- 07072012000400031
Soares PBM, Quirino Filho S, Souza WP, Goncalves RCR, Martelli DRB, Silveira MF, et al. Caracteristicas das mulheres com cancer de mama assistidas em servicos de referencia do Norte de Minas Gerais. Rev Bras Epidemiol. 2012;15(3):595‑604. http://dx.doi.org/10.1590/S1415-790X2012000300013
Peiris H, Mudduwa L, Thalagala N, Jayatialake K. The value of Nottingham grade in breast cancer re-visited in the Sri Lankan setting. Malays J Pathol. 2017;39(2):141-8.
Almeida AMPT, Marquini HR, Leite RM, Nai GA. Prevalencia de cancer de mama e associacao com seus fatores prognosticos e preditivos. Colloquium Vitae. 2012;4(1):27-37.
Stafin I, Caponi LGF, Torres TP, Araujo JN, Guedes VR. Fatores prognosticos no cancer de mama. HU Rev. 2014;38(3‑4):193‑201.
Delmonico L, Alves G, Amaral LFP. A biologia do cancer de mama e testes moleculares de prognostico. Rev Hupe. 2015;14(Supl. 1):59-65. http://doi.org/10.12957/ rhupe.2015.17928
Carmo PO, Leite ICG, Guerra MR. Sobrevida de mulheres com cancer de mama subtipo luminal assistidas em Juiz de Fora, Minas Gerais, Brasil. Rev Bras Mastologia. 2016;26(3):118-25. http://doi.org/10.5327/Z201600030007RBM
Cirqueira MB, Moreira MAR, Soares LR, Freitas-Jr R. Subtipos moleculares do cancer de mama. Femina. 2011;39(10):499-503.
Blows FM, Driver KE, Schmidt MK, Broeks A, Leeuwen FE, Wesseling J, et al. Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies. Plos Med. 2010;7(5):1-12. https://doi.org/10.1371/journal.pmed.1000279
Barreto-Neto NJS, Pinheiro AB, Oliveira JF, Crusoe NSDR, Bertrand SAB, Machado MCM, et al. Perfil epidemiologico dos subtipos moleculares de carcinoma ductal da mama em populacao de pacientes em Salvador, Bahia. Rev Bras Mastologia. 2014;24(4):98-102. http://doi.org/10.5327/ Z201400040002RBM
Carvalho FM, Bacchi LM, Pincerato KM, Van de Rijn M, Bacchi CE. Geographic differences in the distribution of molecular subtypes of breast cancer in Brazil. BMC Womens Health. 2014;14(102):102. https://doi.org/10.1186/1472-6874-14-102
Casadiego AKR, Bianchi GI. Carcinoma de la mama triple negativo aspectos morfologicos y expresion de CK 5/6. Rev Venez Oncol. 2011;23(1):2-13.
Stival RSM, Prestes ALO, Mansani F. Cancer de mama em mulheres jovens: uma analise do estadiamento clinico inicial e dos subtipos moleculares dos tumores. Rev Bras Mastologia. 2014;24(1):17-22. http://doi.org/10.5327/Z201400010004RBM
Borges TO, Vogt MFB, Salum FCA, Calvano Filho CMC, Wanderley MS, Zaconeta ACM, et al. Avaliacao da taxa de positividade do receptor HER2 e da influencia de tres tipos de biopsia mamaria no resultado imunohistoquimico em mulheres com cancer de mama invasivo no Hospital Universitario de Brasilia. Rev Bras Mastologia. 2012;22(3):83-9.
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Copyright (c) 2019 Hanan Jumah Eid Ahmah Laila, Jenifer Rafaela Grzeczinski Zenkner, Maurício Collares Araújo, José Dionísio de Lima Becker, Adriana Dall’Asta Pereira
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