Clipping de mama cirúrgico para delimitação de dose radioterápica no câncer de mama
Palavras-chave:
Câncer de mama, instrumentos cirúrgicos, radioterapiaResumo
Objetivo: Avaliar o benefício do planejamento radioterápico, envolvendo o uso de clipes cirúrgicos em tratamento conservador de estágio inicial de câncer de mama. Métodos: coorte retrospectiva. Doze (12) pacientes do sexo feminino com câncer de mama foram avaliadas retrospectivamente. Estas mulheres foram submetidas a tratamento conservador da mama em que o leito do tumor foi demarcado com grampos cirúrgicos de titânio 200 para orientar a radioterapia de mama. Os volumes foram calculados. O planejamento de radioterapia no mesmo paciente com dose de reforço guiada por clipes metálicos foi comparado ao planejamento guiado por cicatriz cirúrgica ou por exames de imagem antes do tratamento cirúrgico. Resultados: Foram observadas uma redução de 36,7% no volume total da mama irradiada (p = 0,022), uma redução de 55,7% no volume do reforço (p = 0,001), uma redução de 35,9% (p = 0,001) no volume mamário recebendo a dose de reforço prescrita e uma redução de 4,5% (p = 0,014) na dose máxima aplicada ao pulmão. Conclusões: A colocação do clipe no leito cirúrgico após tratamento conservador para câncer de mama determinou uma redução de 36,7% no volume mamário irradiado e o uso de menor dose de irradiação.
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Referências
National Comprehensive Cancer Network. Breast cancer Clinical Practice Guidelines in Oncology. J Natl Compr
Canc Netw. 2003 Apr;1(2):148-88. http://doi.org/10.6004/jnccn.2003.0016
Marta GN, Hanna SA, Martella E, Silva JLF, Carvalho HA. Câncer de mama estádio inicial e radioterapia: atualização.
Rev Assoc Med Bras. 2011;57(4):468-74. http://dx.doi.org/10.1590/S0104-42302011000400024
Pirlamarla A, Ferro A, Yue NJ, Haffty BG, Goyal S. Optimization of surgical clip placement for breast-conservation therapy. Pract Radiat Oncol. 2014;4(3):153-9. http://dx.doi.org/10.1016/j.prro.2013.07.013
Kovner F, Agay R, Merimsky O, Stadler J, Klausner J, Inbar M. Clips and scar as the guidelines for breast radiation boost after lumpectomy. Eur J Surg Oncol. 1999;25(5):483-6. https://doi.org/10.1053/ejso.1999.0683
Bartelink H, Horiot JC, Poortmans P, Struikmans H, Van den Bogaert W, Barillot I, et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 2001;345(19):1378-87. https://doi.org/10.1056/NEJMoa010874
Bartelink H, Horiot JC, Poortmans PM, Struikmans H, Van den Bogaert W, Fourquet A, et al. Impact of a higher radiation dose onlocal control and survival in breast-conserving therapy of early breastcancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol. 2007;25(22):3259-65. https://doi.org/10.1200/JCO.2007.11.4991
Bartelink H, Maingon P, Poortmans P, Weltens C, Fourquet A, Jager J, et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-yearfollow-up of a randomised phase 3 trial. Lancet Oncol. 2015;16(1):47-56. https://doi.org/10.1016/S1470-2045(14)71156-8
Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet JM, et al. Role of a 10-Gy boost in the conservative treatmentof early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol. 1997;15(3):963-8. https://doi.org/10.1200/JCO.1997.15.3.963
Polgár C, Fodor J, Orosz Z, Major T, Takácsi-Nagy Z, Mangel LC, et al. Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I-II breast cancer first results of the randomized Budapest boost trial. Strahlenther Onkol. 2002;178(11):615-23. https://doi.org/10.1007/s00066-002-1053-1
Tessier E, Héry M, Ramaioli A, et al. Boost in conservative treatment:6 years results of randomized trial (Abstr 345). Breast Cancer Res Treat. 1998;50:203-335. https://doi.org/10.1023/B:BREA.0000013524.28746.0d
Marta GN. A importância da utilização de clips cirúrgicos na delimitação do volume de tratamento do reforço de
dose no planejamento radioterápico. Rev Bras Mastologia. 2016;26(4):186-9. https://doi.org/10.5327/Z201600040009RBM
Hunter MA, McFall TA, Hehr KA. Breast-conserving surgery for primary breast cancer: Necessity for surgical clips to define the tumor bed for radiation planning. Radiology. 1996;200:281-2. https://doi.org/10.1148/radiology.200.1.8657928
Coles CE, Wilson CB, Cumming J, Benson JR, Forouhi P, Wilkinson JS, et al. Titanium clip placement to allow accurate tumour bed localisation following breast conserving surgery – audit on behalf of the IMPORT trial management group. Eur J Surg Oncol. 2009;35:578-82. https://doi.org/10.1016/j.ejso.2008.09.005
Landis DM, Luo W, Song J, Bellon JR, Punglia RS, Wong JS, et al. Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity. Int J Radiat Oncol Biol Phys. 2007;67(5):1299-308. https://doi.org/10.1016/j.ijrobp.2006.11.026
Kirova YM, Fournier-Bidoz N, Servois V, Laki F, Pollet GA, Salmon R, et al. How to boost the breast tumor bed? A
multidisciplinary approach in eight steps. Int J Radiat Oncol Biol Phys. 2008;72(2):494-500. https://doi.org/10.1016/j.
ijrobp.2007.12.059 16. Goldberg H, Prosnitz RG, Olson JA, Marks LB. Definition of Post lumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips. Int J Radiat Oncol Biol Phys. 2005;63(1):209-13. https://doi.org/10.1016/j.ijrobp.2005.01.044
Benda RK, Yasuda G, Sethi A, Gabram SG, Hinerman RW, Mendenhall NP. Breast boost: are we missing the target? Cancer. 2003;97(4):905-9. https://doi.org/10.1002/cncr.11142
Pezner RD, Tan MC, Clancy SL, Chen YJ, Joseph T, Vora NL. Radiation therapy for breast cancer patients who undergo oncoplastic surgery: localization of the tumor bed for the local boost. Am J Clin Oncol. 2013;36(6):535-9. https://doi.org/10.1097/COC.0b013e318256efba
Kirova YM, Castro Pena P, Hijal T, Fournier-Bidoz N, Laki F, Sigal-Zafrani B, et al. Improving the definition of tumor bed boost with the use of surgical clips and image registration in breast cancer patients. Int J Radiat Oncol Biol Phys.
;78(5):1352-5. https://doi.org/10.1016/j.ijrobp.2009.10.049
Furet E, Peurien D, Fournier-Bidoz N, Servois V, Reyal F, Fourquet A, et al. Plastic surgery for breast conservation
therapy: how todefine the volume of the tumor bed for the boost? Eur J Surg Oncol. 2014;40(7):830-4. https://doi.
org/10.1016/j.ejso.2014.03.009
Kirby AN, Jena R, Harris EJ, Evans PM, Crowley C, Gregory DL, et al. Tumour bed delineation for partial breast/breast boost radiotherapy: what is the optimal number of implanted markers? Radiother Oncol. 2013;106(2):231-5. https://doi. org/10.1016/j.radonc.2013.02.003
Belkacémi Y, Fourquet A, Cutuli B, Bourgier C, Hery M, Ganem G, et al. Radiotherapy for invasive breast cancer: guidelines for clinical practice from the French expert review board of Nice/Saint-Paul de Vence. Crit Rev Oncol Hematol. 2011;79(2):91-102. https://doi.org/10.1016/j.critrevonc.2010.06.002
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Copyright (c) 2018 Jailson Rodrigues Mendes, Diego de Carvalho Silva, Taíla Sousa de Moura Fé, Antônio Marques de Medeiros Neto, Walberto Monteiro Neiva Eulálio Filho, Sabas Carlos Vieira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.