Valores preditivos dos nódulos mamários categoria 3 pelo sistema de laudos e registro de dados de imagem da mama submetidos à biópsia percutânea por ultrassonografia

Autores

Palavras-chave:

neoplasias de mama, diagnóstico, biópsia, ultrassonografia

Resumo

Introdução: A classificação do Breast Imaging Reporting and Data System (BI-RADS) permite a padronização dos achados das massas mamárias, com recomendação para o manejo individualizado. Por causa de sua alta frequência, massas classificadas como 3, provavelmente benignas, despertam interesse em melhorar sua caracterização e em estabelecer o comportamento mais adequado. Objetivo: P rimeiramente, d emonstrar o s v alores p reditivos p ositivos e n egativos d a c lassificação d e m assas s ólidas B I-RADS 3 submetidos a biópsia percutânea por ultrassonografia. Em segundo lugar, sugerir conduta de acompanhamento por ultrassonografia diferente nesses achados. Metodologia: Estudamos, retrospectivamente, 480 massas BI-RADS 3, submetidas a biópsia a vácuo ou corebiopsia, com resultado histopatológico conclusivo considerado padrão-ouro. Resultados: De 480 massas em 396 pacientes, 473 eram benignas e 7 malignas. O valor preditivo positivo para malignidade de categoria 3 foi de 1,5% (7/480) e o valor preditivo negativo foi de 98,5%. Conclusão: Em vista da baixa probabilidade de câncer, recomenda-se a realização de ultrassonografia direcionada (second look) de massas classificadas como BI-RADS 3 por especialista em radiologia da mama antes da indicação de um procedimento invasivo, o que reduziria substancialmente o número de biópsias desnecessárias, ansiedade do paciente, bem como possíveis complicações. Isso aumentará a possibilidade de o especialista passar mais tempo em exames realmente necessários e direcionados, definindo melhor os casos de acompanhamento (anual ou semestral) da indicação da investigação em casos específicos.

Downloads

Não há dados estatísticos.

Referências

Mendelson EB, Bohm-Velez M, Berg WA, Whitman GJ, Feldman MI, Madjar H, et al. ACR BI-RADS ultrasound. In: D’Orsi CJ, Sickles EA, Mendelson EB, Morris EA, editors. ACR BI-RADS Atlas: Breast Imaging Reporting and Data System. Reston: American College of Radiology; 2013.

Lee KA, Talati N, Oudsema R, Steinberger S, Margolies LR. BI-RADS 3: Current and Future Use of Probably Benign. Curr Radiol Rep. 2018;6(2):5. https://doi.org/10.1007/s40134-018-0266-8

Jang JY, Kim SM, Kim JH, Jang MJ, Yun BL, Lee JY, et al. Clinical significance of interval changes in breast lesions initially categorized as probably benign on breast ultrasound. Medicine. 2017;96(12):e6415. https://doi.org/10.1097/MD.0000000000006415

Alimoglu E, Bayraktar SD, Bozkurt S, Ceken K, Kabaalioglu A, Apaydin A, et al. Follow-up versus tissue diagnosis in BI-RADS category 3 solid breast lesions at US: a cost-consequence analysis. Diagn Interv Radiol. 2012;18(1):3-10. https://doi.org/10.4261/1305-3825.DIR.4462-11.1

Kim SY, Han BK, Kim EK, Choi WJ, Choi Y, Kim HH, et al. Breast Cancer Detected at Screening US: Survival Rates and Clinical-Pathologic and Imaging factors Associated with Recurrence. Radiology. 2017;284(2):354-64. https://doi.org/10.1148/radiol.2017162348

Calas MJG, Koch HA, Dutra MVP. Ultra-sonografia mamaria: avaliacao dos criterios ecograficos na diferenciacao das lesoes mamarias. Radiol Bras. 2007;40(1):1-7. http://dx.doi.org/10.1590/S0100-39842007000100003

Calas MJG, Almeida RMVR, Gutfilen B, Pereira WCA. Interobserver concordance in the BI-RADS classification of breast ultrasound exams. Clinics. 2012;67(2):185-9. https://dx.doi.org/10.6061%2Fclinics%2F2012(02)16

Lee S, Jung Y, Bae Y. Synchronous BI-RADS Category 3 Lesions on Preoperative Ultrasonography in Patients with Breast Cancer: Is Short-Term Follow-Up Appropriate? J Breast Cancer. 2015;18(2):181-6. https://doi.org/10.4048/jbc.2015.18.2.181

Borders MH, Cheng L, Fitzpatrick KA, Krupinski EA. Patient Compliance in the Setting of BI‐RADS Category 3: What Factors Impact Compliance With Short‐Term Follow‐Up Recommendations? Breast J. 2016;23(1):77-82. https://doi.org/10.1111/tbj.12687

Gruber R, Jaromi S, Rudas M, Pfari G, Riedl CC, Flory D, et al. Histologic work-up of non-palpable breast lesions classified as probably benign at initial mammography and/or ultrasound (BI-RADS category 3). Eur J Radiol. 2013;82(3):398-403. https://doi.org/10.1016/j.ejrad.2012.02.004

Moon HJ, Kim MJ, Yoon JH, Kim EK. Follow-up interval for probably benign beast lesion on screening ultrasound in women at average risk for breast cancer with dense breasts. Acta Radiol. 2018;59(9):1045-50. https://doi.org/10.1177/0284185117745906

Kapsimalakou S, Waldmann A, Katalinic A, Grande-Nagel I, Fischer D, Barkhausen J, et al. Follow-up of probably benign lesions in non-screening breast diagnostics. Arch Gynecol Obstet. 2014;290(3):543-51. https://doi.org/10.1007/s00404-014-3233-5

Sickles EA. Probably benign breast lesions: when should follow-up be recommended and what is the optimal follow-up protocol? Radiology. 1999;213(1):11-4. https://doi.org/10.1148/radiology.213.1.r99oc4611

Chala L, Endo E, Kim S, Castro F, Moraes P, Cerri G, et al. Grayscale sonography of solid breast masses: diagnosis of probably benign masses and reduction of the number of biopsies. J Clin Ultrasound. 2007;35(1):9-19. https://doi.org/10.1002/jcu.20298

Elverici E, Zengin B, Barca AN, Yilmaz PD, Alimli A, Araz L. Interobserver and intraobserver agreement of sonographic BIRADS lexicon in the assessment of breast masses. Iran J Radiol. 2013;10(3):122-7. https://dx.doi.org/10.5812%2Firanjradiol.10708

Graf O, Helbich TH, Hopf G, Graf C, Sickles EA. Probably benign breast masses at US: is follow-up an acceptable alternative to biopsy? Radiology. 2007;244(1):87-93. https://doi.org/10.1148/radiol.2441060258

Berg WA, Zhang Z, Cormack JB, Mendelson EB. Multiple Bilateral Circumscribed Masses at Screening Breast US: Consider Annual Follow-up. Radiology. 2013;268(3):673-83. https://doi.org/10.1148/radiol.13122251

Kim K, Song MK, Kim E-K, Yoon JH. Clinical application of S-Detect to breast masses on ultrasonography: a study evaluating the diagnostic performance and agreement with a dedicated breast radiologist. Ultrasonography. 2017;36(1):3-9. https://doi.org/10.14366/usg.16012

Stavros AT, Thickman D, Rapp CL, Dennis MA, Parker SH, Sisney GA. Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. Radiology. 1995;196(1):123-34. https://doi.org/10.1148/radiology.196.1.7784555

Barr RG, Zhang Z, Cormack JB, Mendelson EB, Berg WA. Probably benign lesions at screening breast US in a population with elevated risk: prevalence and rate of malignancy in the ACRIN 6666 trial. Radiology. 2013;269(3):701-12. https://doi.org/10.1148/radiol.13122829

Nam SY, Ko EY, Han B-K, Shin JH, Ko ES, Hahn SY. Breast Imaging Reporting and Data System Category 3 Lesions Detected on Whole-Breast Screening Ultrasound. J Breast Cancer. 2016;19(3):301-7. https://dx.doi.org/10.4048%2Fjbc.2016.19.3.301

Park YM, Kim EK, Lee JH, Ryu JH, Han SS, Choi SJ, et al. Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred? Acta Radiol. 2008;49(10):1104-11. https://doi.org/10.1080/02841850802438504

Ha SM, Chae EY, Cha JH, Shin HJ, Choi WJ, Kim HH. Growing BI-RADS category 3 lesions on follow-up breast ultrasound: malignancy rates and worrisome features. Br J Radiol. 2018;91(1087):20170787. https://doi.org/10.1259/bjr.20170787

Badan GM, Roveda Junior D, Ferreira CAP, Ferreira FAT, Fleury EFC, Campos MSCA, et al. Valores preditivos positivos das categorias 3, 4 e 5 do Breast Imaging Reporting and Data System (BI-RADS®) em lesoes mamarias submetidas a biopsia percutanea. Radiol Bras. 2013;46(4):209-13. http://dx.doi.org/10.1590/S0100-39842013000400006

Raza S, Chikarmane SA, Neilsen SS, Zorn LM, Birdwell RL. BIRADS 3, 4, and 5 lesions: value of US in management: followup and outcome. Radiology. 2008;248(3):773-81. https://doi.org/10.1148/radiol.2483071786

Abdullah N, Mesurolle B, El-Khoury M, Kao E. Breast Imaging Reporting and Data System Lexicon for US: Interobserver Agreement for Assessment of Breast Masses. Radiology. 2009;252(3):665-672. https://doi.org/10.1148/radiol.2523080670

Shin JH, Han BK, Ko EY, Choe YH, Nam SJ. Probably benign breast masses diagnosed by sonography: is there a difference in the cancer rate according to palpability? AJR Am J Roentgenol. 2009;192(4):W187-91. https://doi.org/10.2214/AJR.08.1404

Calas MJG, Almeida RMVR, B. Gutfilen B, Pereira WCA. Intraobserver interpretation of breast ultrasonography following the BI-RADS classification. Eur J Radiol. 2010;74(3):525-8. https://doi.org/10.1016/j.ejrad.2009.04.015

Kim SJ, Chang JM, Cho N, Chung SY, Han W, Moon WK. Outcome of breast lesions detected at screening ultrasonography. Eur J Radiol. 2012;81(11):3229-33. https://doi.org/10.1016/j.ejrad.2012.04.019

Ackermann S, Schoenenberger C-A, Zanetti-Dallenbach R. Clinical Data as an Adjunct to Ultrasound Reduces the False- Negative Malignancy Rate in BI-RADS 3 Breast Lesions. Ultrasound International Open. 2016;2(3):E83-9. https://dx.doi.org/10.1055%2Fs-0042-110657

Downloads

Publicado

2019-07-29

Como Citar

Gonçalves, L. P., Lemos, M. L., & Calas, M. J. G. (2019). Valores preditivos dos nódulos mamários categoria 3 pelo sistema de laudos e registro de dados de imagem da mama submetidos à biópsia percutânea por ultrassonografia. Mastology, 29(3), 118–124. Recuperado de https://revistamastology.emnuvens.com.br/revista/article/view/591

Edição

Seção

Original Articles