Disruptores endócrinos e o seu papel na gênese das neoplasias e de outras patologias das mamas

Autores

  • Mauri José Piazza Universidade Federal do Paraná
  • Almir Antônio Urbanetz Universidade Federal do Paraná
  • Cicero Urban Universidade Positivo

Palavras-chave:

Mama, câncer de mama, neoplasias da mama

Resumo

Uma maior ocorrência no surgimento precoce das neoplasias das mamas em mulheres tem gerado a necessidade da descoberta dos possíveis agentes etiológicos caracterizados como corresponsáveis diretos. A relevância da detecção dos possíveis disruptores endócrinos responsáveis por exercer efeitos danosos nos tecidos mamários e, consequentemente, o seu comprometimento é a motivação da presente revisão.

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Biografia do Autor

Mauri José Piazza, Universidade Federal do Paraná

Department of Obstetrics and Gynecology, Universidade Federal do Paraná

Referências

Dodds EC, Lawson W. Synthetic oestrogen agents without the phenanthrene nucleus. Nature. 1936;137:996. https://doi.org/10.1038/137996a0

Vom Saal FS, Welshons WV. Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure. Moll Cell Endocrinol. 2014;398:101-

https://dx.doi.org/10.1016%2Fj.mce.2014.09.028 3. Völkel W, Colnot T, Csanády GA, Filser JG, Dekant W. Metabolism and kinetics of bisphenol A in humans at low doses following oral administration. Chem Res Toxicol. 2002;15:1281-7.

Teeguarden JG, Twaddle NC, Churchwell MI, Yang X, Fisher JW, Seryak LM, et al. 24-hour human urine and sérum profiles of bisphenol A; evidence against sublingual absorption following ingestion in soup. Toxicol Appl Pharmacol. 2015;288:131-42. https://doi.org/10.1016/j.taap.2015.01.009

Wu CF, Chang-Chien GP, Su SW, Chen BH, Wu MT. Findings of 2731 suspected phtalate-painted foodstuffs during the 2011 phtalates incident in Taiwan. J Formos Med Assoc. 2014;113:600-5. https://doi.org/10.1016/j.jfma.2014.02.010

Solomon KR, Giesy JP, LaPoint TW, Giddings JM, Richards RP. Ecological risk assessment of atrazine in North American surface waters. Environ Toxicol Chem. 2013;32:10-1. https://doi.org/10.1002/etc.2050

Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. The E-Screen assay as a tool to identify estrogen: an update on estrogenic environmental pollutants. Environ Health Perspect. 1995;103(suppl 7):113-22.

Portigal CL, Cowell SP, Fedoruk MN, Butler CM, Rennie OS, Nelson CC. Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone biding. Toxicol Appl Pharmacol. 2002;179:185-94. https://doi.org/10.1006/taap.2002.9371

Agency for Toxic Substances and Disease Registry. Toxicological Profile for Polybrominated Biphenyls and Polybrominated Diphenyl Ethers (PBBs and PBDEs). Atlanta: US Department of Health and Human Services, Public Health Service; 2004.

Knower KC, To SQ, Leung YK, Ho SM, Clyne CD. Endocrine disruption of the epigenome: a breast cancer link. Endocr Relat Cancer. 2014;21:T33-55. https://doi.org/10.1530/ERC-13-0513

National Toxicology Program. Report on Carcinogens. 12ª ed. Washington, D.C.: U.S. Department of Health and Human Services, Public Health Service; 2011.

Dodds EC, Lawson W, Robison R. Estrogenic activity of certain synthetic compounds. Nature. 1938;141:247-8. https://doi.org/10.1038/141247b0

Dieckmann WJ, Davis ME, Rinkiewicz LM, Pottinger RE. Does the administration of diethylbestrol during the pregnancy have therapeutic value? Amer J Obstet Gynecol. 1953;66:1062-81.

Herbst AL, Ulfelder H, Postkanger DC. Adenocarcinoma of vagina. Association of maternal stilbestrol therapy with tumor appearance in Young women. N Engl J Med. 1971;284:878-81. https://doi.org/10.1056/NEJM197104222841604

Herbst AL. Summary of changes in human female genital tract as a consequence of maternal diethylstilbestrol therapy. J Toxicol Environ Health Suppl. 1976;1:13-20.

Harris RM, Waring RN. Diethylstilbestrol-a long term legacy. Maturitas. 2012;72:108-12. https://doi.org/10.1016/j.maturitas.2012.03.002

Troisi R, Hyer M, Hatch EE, Titus-Ernstoff L, Palmer JR, Strohsnitter WC, et al. Medical conditions among adults offspring prenatally exposed to diethylstilbestrol. Epidemiology. 2013;24:430-8. https://doi.org/10.1097/EDE.0b013e318289bdf7

National Toxicology Program. Carcinogenesis bioassay of bisphenol A (CAS No 80-05-7) in F344 rats and B6C3F1 mice (feed study). Natl Toxicol Program Tech Rep Ser. 1982 Mar;215:1-116.

Timms BG, Howdeshell KL, Barton L, Bradley S, Richterand CA, Saal FSV, et al. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proc Natl Acad Sci U S A. 2005;102(19):7014-9. https://doi.org/10.1073/pnas.0502544102

Moral R, Wang R, Russo IH, Lamartiniere CA, Pereira J, Russo J. Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression. Signature. J Endocrinol. 2008;196(1):101-12. https://doi.org/10.1677/JOE-07-0056

Jenkins S, Raghuraman N, Eltoum I, Carpenter M, Russo J, Lamartiniere CA. Oral exposure to bisphenol A increaes dimethylbenzanthracene-induced mammary cancer in rats. Environ Health Perspect. 2009;117(6):910-5. https://doi.org/10.1289/ehp.11751

Prins GS, Ye SH, Birch L, Ho SM, Kannan K. Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposure in neonatal Sprague_Dawley rats. Reprod Toxicol. 2011;31(1):1-9. https://doi.org/10.1016/j.reprotox.2010.09.009

Soto AM, Chung S, Sonnenschein C. The pesticides endosulfan, toxaphene and dieldrin have estrogenic effects on human estrogenic-sensitive cells. Environ Health Perspect. 1994;102(4):380-3.

Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JÁ, Wilson EM. Persistent DDT metabolite p.p’-DDE is a potente androgen receptor antagonista. Nature. 1995;375:581-5. https://doi.org/10.1038/375581a0

Moore M, Mustain M, Daniel K, Chen I, Safe S, Zacharewski T, et al. Antiestrogenic activity of hidroxilated polychlorinated biphenyl congeners identified in human serum. Toxicol Appl Pharmacol. 1997;142:160-8. https://doi.org/10.1006/taap.1996.8022

Astroff B, Safe S. 2,3,7,8-tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Biochem Pharmacol. 1990;39:485-8.

Den Hond E, Roels HÁ, Hoppenbrouwers K, Nawrot T, Thijs L, Vandermeulen C, et al. Sexual maturation in relation to plychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek’s hypothesis revisited. Environ Health Perspect. 2002;110:771-6.

Leijs MM, Koppe JG, Olie K, van Aalderen WM, Voogt Pd, Vulsma T, et al. Delayed initiation of breast development in girls with higher prenatal dioxin exposure: a longitudinal cohort study. Chemosphere. 2008;73:999-1004. https://doi.org/10.1016/j.chemosphere.2008.05.053

Bertazzi PA, Zocchetti C, Pesatori AC, Guercilena S, Sanarico M, Radice L. Ten-year mortality study of the population involved in the Seveso-incident in 1976. Am J Epidemiol. 1989;129:1187-200.

Bertazzi PA, Zocchetti C, Guercilena S, Consonni D, Tironi A, Landi MT, et al. Dioxin exposure and câncer risk: a 15-year mortality study after the Seveso-incident. Epidemiology. 1997;8:646-52.

Pesatori AC, Consonni D, Rubagotti M, Grillo P, Bertazzi PA. Cancer incidence in the population exposed to dioxin after the Seveso accident: twenty years of follow-up. Environ Health. 2009;8:39. https://doi.org/10.1186/1476-069X-8-39

Warner M, Eskenazi B, Mocarelli P, Gerthoux PM, Samuels S, Needham L, et al. Serum dioxina concentrations and breast câncer risk in the Seveso Women’s Health Study. Environ Health Perspect. 2002;110:625-8.

Revich B, Aksel E, Ushakova T, Ivanova I, Zhuchenko N, Klyuev N, et al. Dioxin exposure and public health in Chapayevsk, Russia. Chemosphere. 2001;43:951-66.

Fenton SE, Hamm JT, Birnbaum LS, Youngblood GL. Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8 tetrachlorodibenzeno-pdioxin (TCDD). Toxicol Sci. 2002;67:63-74.

Lewis BC, Hudgins S, Lewis A, Schorr K, Sommer R, Peterson RE, et al. In utero and lactational treatment with 2,3,7,8 tetrachlorodibenzeno-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat. Toxicol Sci. 2001;62:46-53.

Brown NM, Manzolillo PA, Zhang JX, Wang J, Lamartiniere CA. Prenatal TCDD and predisposition to mammary câncer in the rat. Carcinogenesis. 1998;19:1623-9.

Desaulniers D, Leingsrtner K, Russo J, Perkins G, Chittim BG, Archer MC, et al. Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p.p’-DDT and p.p’-DDE, on methylnitrosourea induced mammary tumor development in the rat. Environ Health Perspect. 2001;109:739-47.

Rogan WJ, Gladen BC, Mckinney JD, Carreras N, Hardy P, Thullen J, et al. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects on growth, morbidity and duration of lactation. Am J Publ Health. 1987;77:1294-7.

Karmaus W, Davis S, Fussman C, Brooks K. Maternal concentrations of dichlorodiphenyl dichloroethylene (DDE) and initiation and duration of breast feeding. Paediatr Perinat Epidemiol. 2005;19:388-98. https://doi.org/10.1111/j.1365-3016.2005.00658.x

Wasserman M, Nogueira L, Tomatis AP, Mirra H, Shibata G, Arie G, et al. Organochlorine compounds in neoplastic and apparently normal breast tissue. Bull Environ Contam Toxicol. 1976;15(4):478-84.

Unger M, Kiaer M, Blichert-Toft M, Olsen J, Clausen J. Organochlorine compounds in human breast fat from deceased with and without breast câncer and in a biopsy material from newly diagnosed patients undergoing breast surgery. Environ Res. 1984;34:24-8.

Mussalo-Rauhamaa H, Häsänen E, Pyysalo K, Antervo R, Kauppila R, Pantzar P. Occurrence of beta- exachlorocyclohexane in breast cancer patients. Cancer. 1990;66:2124-8. https://doi.org/10.1002/1097-0142(19901115)66:10%3C2124::AIDCNCR2820661014%3E3.0.CO;2-A

Falck F Jr, Ricci A Jr, Wolff MS, Godbold J, Deckers P. Pesticides and polychlorinated byphenils residues in human breast lipids and their relation to breast cancer. Arch Environ Health. 1992;47:143-6.

Dewailly E, Bruneau S, Ayotte P, Laliberté C, Gringas S, Bélanger D, et al. Health status at birth of Inuit newborns prenatally exposed to organochlorines. Chemosphere. 1993;27:359-66. https://doi.org/10.1016/0045-6535(93)90313-T

Wolff MS, Toniolo PG, Lee EW, Rivera M, Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J Natl Can Inst. 1993;85:648-52.

Krieger N, Wolff MS, Hiatt RA, Rivera M, Vogelman J, Orentreich N. Breast cancer and serum organochlorines: a prospective study among White, black and Asian women. J Natl Cancer Inst. 1994;86:589-99.

van’t Veer P, Lobbezoo IE, Martín-Moreno JM, Guallar E, Gomez-Aracena J, Kardinaal AF, et al. DDT (dicophane)and postmenopausal breast câncer in Europe:Case control study. BMJ. 1997;315:81-5. https://doi.org/10.1136/bmj.315.7100.81

Liljegren G, Hardell L, Lindström G, Dahl P, Magnuson A. Case-control study on breast câncer and adipose tissue concentrations of congener specific polychlorinated biphenyls DDE and hexachlorobenzene. Eur J Cancer Prev. 1998;7:135-40.

Güttes SK, Failing K, Neumann K, Kleinstein J, Georgii S, Brunn H. Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol. 1998;35:140-7.

Sutherland SE, Bernard VB, Keil JE, Austin H, Hoel DG. Pesticides and twenty years risk of breast cancer. 29th Annual Meeting of the Society for Epidemiologic Research, Boston MA. Am J Epidemiol (Abstracts). 1996;143:133.

Hunter DJ, Hankinson SE, Laden F, Colditz GA, Manson JE, Willett WC, et al. Plasma organochlorine levels and the risk of breast câncer. N Engl J Med. 1997;337:1253-8. https://doi.org/10.1056/NEJM199710303371801

López-Carrillo L, Blair A, López-Cervantes M, Cebrián M, Rueda R, Reyes R, et al. Dichlorodiphenyltrichloroethane serum levels and breast cancer risk: a case control study from Mexico. Cancer Res. 1997;57:3728-32.

Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB. Organochlorine exposure and risk of breast cancer. Lancet. 1998;352:1816-20. https://doi.org/10.1016/S0140-6736(98) 04504-8

Cohn BA, Wolff MS, Cirillo PM, Sholtz RI. DDT and breast cancer in Young women: new data on the significance of age at exposure. Environ Health Perspect. 2007;115:1406-14. https://dx.doi.org/10.1289%2Fehp.10260

Boada LD, Zumbado M, Henríquez-Hernández LA, Almeida-González M, Alvarez-León EE, Serra-Majem L, et al. Complex organochlorine pesticide mixtures as determinant factor for breast cancer risk: a population-based case-control study in the Canary Islands (Spain). Environ Health. 2012;11:28. https://doi.org/10.1186/1476-069X-11-28

White AJ, Teitelbaum SL, Wolff MS, Stellman SD, Neugut AI, Gammon MD. Exposure to fogger trucks and breast câncer incidence in the Long Island Cancer Study Project: a case-control study. Environ Health. 2013;12:24. https://doi.org/10.1186/1476-069X-12-24

Ingber SZ, Buser MC, Pohl HR, Abadin HG, Murray HE, Scinicariello F. DDT/DDE and breast cancer: a meta-analysis. Regul Toxicol Pharmacol. 2013;67:421-33. https://doi.org/10.1016/j.yrtph.2013.08.021

Pupo M, Pisano A, Lappano R, Santolla MF, Francesco EM, Abonante S, et al. Bisphenol A induces gene expression. Changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts. Environ Health Perspect. 2012;120:1177-82. https://doi.org/10.1289/ ehp.1104526

Takayanagi S, Tokunaga T, Liu X, Okada H, Matsushima A, Shimohigashi Y. Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor ERR with high constitutive activity. Toxicol Lett. 2006;167:95-105. https://doi.org/10.1016/j.toxlet.2006.08.012

Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D. Bisphennol A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology. 1993;132:2279-86. https://doi.org/10.1210/endo.132.6.8504731

Markey CM, Luque EH, Munoz-de-Toro M, Sonnenschein C, Soto AM. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod. 2001;65:1215-23.

Munoz-de-Toro M, Markey CM, Wadia PR, Luque EH, Rubin BS, Sonnenschein C, et al. Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology. 2005;146:4138-47. https://dx.doi.org/10.1210%2Fen.2005-0340

Acevedo N, Davis B, Schaeberle CM, Sonnenschein C, Soto AM. Perinatally administered bisphenol A as a potente mammary gland carcinogen in rats. Environ Health Perspect. 2013;121:1040-6. https://doi.org/10.1289/ehp.1306734

Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, et al. Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90. Toxicol. 2014;139:174-97. https://doi.org/10.1093/toxsci/kfu022

Henderson AK, Rosen D, Miller GL, Figgs LW, Zahm SH, Sieber SM, et al. Breast cancer among women exposed topolybrominated bisphenyls. Epidemiology. 1995;6:544-6.

Wolff MS, Teitelbaum SL, McGovern K, Windham GC, Pinney SM, Galvez M, et al. Phthalate exposure and pubertal development in a longitudinal study of US girls. Hum Reprod. 2014;29:1558-66. https://doi.org/10.1093/humrep/deu081

López-Carrillo L, Hernández-Ramírez RU, Calafat AM, Torres-Sánchez L, Galván-Portillo M, Needham LL, et al. Exposure to phthalates and breast cancer risk in northern Mexico. Environ Health Perspect. 2010;118: 539-44. https://doi.org/10.1289/ehp.0901091

Moral R, Santucci-Pereira J, Wang R, Russo IH, Lamartiniere CA, Russo J. In utero exposure to butyl benzyl phthalate induces modifications in the morphology and gene expression. Profile of the mammary gland: an experimental study in rats. Environ Health. 2011;10:5. https://dx.doi.org/10.1186%2F1476-069X-10-5

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Publicado

2018-10-28

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Piazza, M. J., Urbanetz, A. A., & Urban, C. (2018). Disruptores endócrinos e o seu papel na gênese das neoplasias e de outras patologias das mamas. Mastology, 28(4), 257–267. Recuperado de https://revistamastology.emnuvens.com.br/revista/article/view/929

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Review Articles